Recent advances in molecular biology have called into question the hitherto prevailing dogma of: one gene, one protein, one disease.
Today the cell should be considered as a whole with all its component entities. Proteins are known to be capable of influencing DNA or interacting with each other, and RNA can disrupt other proteins or be sensitive to different signals etc. These are just some of the phenomena to be studied in order to understand better the functioning of the cell and draw out new therapeutic leads. This is one of the priorities the AFM fixed in 2005.

Therefore it financed ten research projects within the framework of a specific “Proteic interactions in neuromuscular physiopathology” call for proposals. One of the projects concerns an ambitious programme launched by Généthon in collaboration with the company Hybrigenics – to draw up a comprehensive protein map of the muscle cell and its interactions.
In the same field the Décrypthon programme leads to joint AFM-CNRS-IBM calls for proposals.